Combination medication is an important means to improve the level of drug treatment, especially when mixed infections that cannot be controlled by a single drug and serious infections of unknown etiology occur in clinical practice, it is necessary to combine medication for chickens.
How to combine medication for best effect?
In the process of combining the two drugs, three different results will be produced, namely synergy, additive and antagonistic. The so-called drug synergy means that the total efficacy of the two drugs is enhanced after combined use, that is, 1+1>2, which is also the purpose of combined drug use. How to use colistin sulfate synergistically in chicken farms? Veterinarian: 3 ways to match, double the efficacy
(1) Colistin sulfate + Florfenicol
Colistin sulfate increases the permeability of the cell membrane, which is conducive to the entry of Florfenicol into bacterial cells and further blocks the synthesis of bacterial proteins. The combination of the two drugs, combined inside and outside, synergistic sterilization, not only enhances the bactericidal effect, but also expands the Antibacterial spectrum, ie 1+1>2.
Double the therapeutic effect on intestinal bacterial infections caused by Escherichia coli, Salmonella, Shigella, Shigella, Clostridium perfringens, etc. Have efficient killing effect.
(2) Colistin sulfate + Amoxicillin
Compound Amoxicillin and Colistin sulfate belong to reproductive stage fungicides (Class I) and stationary phase fungicides (Class II) respectively. The two drugs are used in combination and cooperate with each other, which not only reduces the generation of drug resistance, but also improves the bactericidal effect. , that is, 1+1>2. Double the therapeutic effect on the mixed infection of intestinal bacteria caused by chicken E. coli, Salmonella, Shigella, and Escherichia coli.
(3) Colistin sulfate + Neomycin sulfate
Colistin sulfate increases the permeability of the cell membrane, which is conducive to the entry of neomycin sulfate into bacterial cells and further blocks the synthesis of bacterial proteins. The combination of the two drugs enhances the antibacterial effect.
It has a good effect on intractable diarrhea, enterotoxemia and overfeeding caused by chicken Escherichia coli, Salmonella, and Clostridium perfringens.
In general, combined drug use is an important means to improve the level of drug treatment. The combined use of drugs with synergistic effects can give full play to the efficacy of drugs, reduce the toxic and side effects of drugs, and reduce the production of drug-resistant bacteria. contribute.
This article is for reference only, please use the specific medication under the guidance of a licensed veterinarian
