Amoxicillin and Enrofloxacin are two products commonly used in the veterinary market, different dosage forms have different methods of use, how to use the combination to play a better efficacy?
Enrofloxacin is a fluoroquinolone synthetic antibacterial drug for animals, which has a strong bactericidal effect on Gram-positive and Gram-negative bacteria and mycoplasma, with stronger anti-mycoplasma activity than macrolides, and is a fast-acting bactericidal drug during the reproduction period.
At present, the common dosage forms on the market are Enrofloxacin injection and Enrofloxacin soluble powder. Enrofloxacin injection is a necessary drug for pig farms, while Enrofloxacin soluble powder has not been widely used in pig farming for many years due to its bitter taste and bad palatability for pigs, which should not be taken internally; in the past two years, in order to adapt to the palatability of pigs, manufacturers have microencapsulated it to cover its original bitter taste and increase the palatability of pigs, plus Enrofloxacin has a broad-spectrum bactericidal effect. It has good effect on livestock and poultry respiratory and intestinal infections, and slowly it has been widely used in pig farming and achieved good results.
Amoxicillin belongs to β-lactam penicillin broad-spectrum antibiotics, has bactericidal effect on both Gram-positive and negative bacteria, belongs to the reproduction period of fast-acting bactericidal drugs, especially for livestock and poultry lung infections have better efficacy.
At present, the common dosage forms in the market areAmoxicillin soluble powder andAmoxicillin sodium for injection. Because of its fast bactericidal effect and little toxic side effects, it is widely used in livestock and poultry, especially for daily health care of sows during gestation, and has good effect on respiratory and intestinal infections of pigs, especially for streptococcal and postpartum infections of sows with unique therapeutic effect.
According to the principle of combination of anti-microbial drugs in pharmacology, Enrofloxacin andAmoxicillin are both fast-acting bactericidal drugs in reproduction period, and they have synergistic effect when used in combination; according to the physical and chemical properties of the two in pharmacology, different dosage forms have different ways of combination. The specific product pairing is as follows.
1. Enrofloxacin soluble powder (encapsulated) +Amoxicillin soluble powder, according to the ratio of different specifications of the two, mixed with feed, synergistic effect, suitable for the daily health care of pigs at all stages (piglets, fattening pigs, sows, breeding pigs) (except for sows in gestation, because Enrofloxacin has toxic side effects on embryos), once a month, to prevent various bacterial respiratory diseases and intestinal diseases in pig farms, reduce the incidence of It can prevent various bacterial respiratory diseases and intestinal diseases in pig farms, reduce the incidence of related diseases and improve the economic benefits of pig farms.
2. Enrofloxacin injection (national standard) +Amoxicillin sodium for injection, diluteAmoxicillin sodium for injection with Enrofloxacin injection, mix with intramuscular injection, synergistic effect, applicable to symptoms such as leg lameness, joint enlargement, joint pain, lameness and unstable standing of pigs caused by unknown reasons, such as related symptoms caused by Haemophilus parvum, Streptococcus arthritis, etc.
