Florfenicol is widely used in the breeding process, the following are some precautions in the process of use:
1. Florfenicol should not be used in combination with macrolides (such as tylosin, erythromycin, roxithromycin, tilmicosin, guitaromycin, azithromycin, clarithromycin, etc.), lincosamides (such as lincomycin, clindamycin) and diterpene semi-synthetic antibiotics – tylosin, florfenicol can produce antagonistic effects when combined with these products.
2. Florfenicol should not be used in combination with β-lactone amines (such as penicillin, cephalosporins) and fluoroquinolones (such as enrofloxacin, ciprofloxacin, etc.), because this product is a fast-acting antibacterial agent that inhibits bacterial protein synthesis, and the latter is a fast-acting bactericidal agent during the reproduction period. Under the action of the former, bacterial protein synthesis is rapidly inhibited, and bacteria stop growing and reproducing, so that the bactericidal effect of the latter is weakened. Therefore, in the treatment of the need to play a rapid bactericidal effect, can not be used together.
3. Florfenicol should not be mixed with sodium sulfadiazine for intramuscular injection. It should not be combined with alkaline drugs when administered orally or intramuscularly to avoid decomposition and failure. It should not be mixed with tetracycline hydrochloride, kanamycin, adenosine triphosphate and coenzyme A for intravenous injection to avoid precipitation and reduced effectiveness.
4. Florfenicol may cause muscle degeneration and necrosis after intramuscular injection, therefore, it can be alternately injected into the deep muscles of the neck and buttocks, and should not be repeatedly injected in the same area.
5. Florfenicol may have embryotoxicity, so use with caution during pregnancy and lactating sows.
6.Florfenicol can be used with antipyretic and analgesic drugs and dexamethasone when the body temperature of sick pigs is high, the effect is better.
7.In the prevention and control of porcine respiratory syndrome (PRDC), florfenicol and amoxicillin, florfenicol and tylosin, florfenicol and tamoxifen, etc., from the pharmacological point of view, they cannot be combined. However, florfenicol can be used in combination with tetracycline, such as doxycycline, for better effect!
8.Although it does not cause irreversible aplastic anemia, it causes more common reversible erythropoiesis than chloramphenicol (which is prohibited). It is prohibited during the vaccination period or in animals with severe immune deficiency.
9. If florfenicol is found to dissolve slowly at low temperature, or if there is precipitation of florfenicol from the prepared solution, it can be dissolved quickly by only slightly increasing the temperature (not more than 45℃). The solution should be used up within 48 hours.
It is very safe to use the appropriate dosage form, method of use and recommended dosage as described above. Individual animals may experience a temporary decrease in appetite, reduced water intake or diarrhea, slight pain at the site of injection and mild tissue reactions, all of which are normal and will return to normal after discontinuation.
(This article is for reference only, please use under the guidance of a licensed veterinarian for specific medication)
