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Ampicillin Trihydrate
CAS No.
Appearance
Purity
Molecular Formula
Molecular Weight
Solubility
Synonyms
Table of Contents
Overview
Ampicillin Trihydrate is a semi-synthetic broad-spectrum β-lactam antibiotic belonging to the aminopenicillin group.
It shows potent activity against Gram-positive bacteria and certain Gram-negative organisms, making it widely used in veterinary formulations including oral powders, injectables, and premixes.
This product complies with major pharmacopoeial requirements, ensuring high purity, strong stability, and consistent antimicrobial performance.
Widely used by veterinary pharmaceutical manufacturers, Ampicillin Trihydrate offers reliable performance in water-soluble powders, injectables, and premix applications, supported by consistent batch-to-batch quality.
Product Information
Active Ingredient: Ampicillin Trihydrate
CAS Number: 7177-48-2
Chemical Name: (2S,5R,6R)-6-[(R)-2-Amino-2-phenylacetamido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate
Molecular Formula: C16H19N3O4S
Molecular Weight: 349.40
Mode of Action:
Ampicillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), resulting in bactericidal activity.
Indications:
Effective against susceptible strains of:
- Streptococcus spp.
- Staphylococcus spp. (non-β-lactamase producing)
- Pasteurella spp.
- Escherichia coli (selected strains)
- Clostridium spp.
Target Species: Poultry, Swine, Cattle, Sheep, Goats
Dosage Form: API for veterinary formulations
Technical Specifications
| Appearance | White or almost white crystalline powder |
| Identification | IR: Conforms to reference spectrum |
| Appearance of Solution | Not more opalescent than reference suspension II |
| Water Content | 12.0% – 15.0% |
| pH (2%, w/v) | 3.5 – 5.5 |
| Specific Optical Rotation | +280° to +305° (anhydrous substance) |
| Related Substances | Any impurity ≤1.0% |
| Sulfated Ash | ≤0.5% |
| N,N-Dimethyl aniline | ≤20 ppm / Not detected |
| Methanol | ≤3000 ppm |
| Assay | 96.0% – 102.0% (calculated on anhydrous basis) |
Quality Assurance
Ampicillin Trihydrate supplied by HOPE BIOTECH is manufactured under GMP-compliant conditions and verified against EP/BP/USP standards.
Each batch undergoes:
- Identity (IR) confirmation
- Assay and potency verification
- Impurity profiling
- Water content / optical rotation tests
- Residual solvent analysis
- Microbial limit testing
All products are shipped with:
-
- COA (Certificate of Analysis)
- MSDS / SDS
- GMP & ISO documentation
- Regulatory dossier support upon request
Our manufacturing partners maintain validated cleaning procedures, controlled residual solvents, and continuous in-process monitoring to ensure microbiological safety and minimal degradation. Stability studies under ICH conditions further guarantee product integrity during long-distance transport and long-term storage.
Applications & Dosage
Ampicillin Trihydrate is commonly used in veterinary medicine for the treatment of bacterial infections affecting the respiratory, digestive, and urinary systems.
Common Veterinary Dosages:
- Poultry: 10–20 mg/kg body weight per day, via drinking water or feed.
- Swine: 8–12 mg/kg body weight per day.
- Cattle & Sheep: 5–10 mg/kg body weight per day.
Dosages may vary depending on formulation, species, and severity of infection. Follow local regulations and veterinarian guidance.
Withholding Period:
- Meat: As per formulation regulations
- Milk: Follow local MRL guidelines
Product FAQ
Q1: What is Ampicillin Trihydrate used for?
Ampicillin Trihydrate is used as a veterinary active pharmaceutical ingredient for treating respiratory, gastrointestinal, and urinary infections caused by susceptible Gram-positive and selected Gram-negative bacteria. It is commonly applied in oral powders, water-soluble formulations, injectables, and premixes.
Q2: What is amoxicillin trihydrate used for?
Amoxicillin Trihydrate is another aminopenicillin antibiotic used to treat bacterial infections in animals, but it differs from Ampicillin in absorption and spectrum. Ampicillin Trihydrate remains preferred for specific veterinary formulations requiring stable β-lactam activity in powder or injectable forms.
（此问必须回答，但保持“与本品区隔”的写法，避免重复内容。）
Q3: Is Ampicillin Trihydrate equivalent to ampicillin?
Yes. Ampicillin Trihydrate is the hydrated crystalline form of ampicillin. It delivers the same antimicrobial activity, with improved stability for storage, handling, and formulation processes in veterinary API manufacturing.
Q4: Is Ampicillin a good antibiotic?
Ampicillin is an effective broad-spectrum β-lactam antibiotic when used against susceptible bacteria. It works by inhibiting bacterial cell wall synthesis and is widely used in veterinary medicine due to its reliable efficacy and well-established safety profile.
Q5: Is Ampicillin Trihydrate safe for animals?
Yes, when used according to recommended dosages and veterinary guidance. Safety depends on species, formulation, and adherence to withdrawal times for meat and milk. Proper storage and handling also help maintain product integrity.
Q1. How can I request a quotation or sample?
You can click the “Send Inquiry” button on this page or email us directly at [email protected].
Samples are available for most products, and our sales team will reply within 24 hours with detailed pricing and documentation .
Q2. What is the minimum order quantity (MOQ)?
The MOQ is 0.5 kg for most products.
For laboratory evaluation or small trial batches, smaller quantities can be arranged depending on stock availability.
Q3. What certifications do your products comply with?
Our GMP-certified partners operate under ISO, CEP, and FSC standards.
Each batch is supplied with a full set of COA, MSDS, and export documents to ensure quality traceability.
Q4. How long does delivery take?
Usually 3–7 working days for available stock and 2–3 weeks for customized specifications or large orders.
Q5. Which payment methods do you accept?
We accept T/T, L/C, and other agreed terms depending on the order volume and region.
Q6. Can you provide contract manufacturing or custom formulation support?
Yes. We cooperate with multiple GMP facilities to offer custom synthesis, formulation, and registration support for specific markets.
Packaging Information
Standard packing: 25 kg fiber drum or 1 kg foil bag
Double PE inner liner for moisture protection
Custom packaging available on request
Storage & Stability
Store in a cool, dry environment away from direct light. Shelf life 24 months under recommended conditions.
Transportation
Shipped by air, sea, or express according to customer preference. Dangerous goods comply with IATA/IMDG standards if applicable.
Our company and partner facilities hold valid GMP and ISO certificates issued by national authorities, ensuring that every batch meets strict quality and traceability standards required for international veterinary API markets.
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