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Azithromycin Dihydrate
CAS No.
Appearance
Purity
Molecular Formula
Molecular Weight
Solubility
Synonyms
Table of Contents
Product Overview
Azithromycin Dihydrate is a semi-synthetic macrolide antibiotic derived from a fermentation product and widely used as a veterinary active pharmaceutical ingredient (API). It is provided as a white to almost white crystalline powder with two molecules of hydration water, offering excellent stability and suitability for use in livestock and poultry formulations.
Its broad-spectrum antibacterial activity covers a wide range of Gram-positive and Gram-negative organisms, making it valuable for oral powders, premixes, and water-soluble preparations. The product is produced under controlled quality systems to ensure consistent purity and compliance for veterinary applications.
For reference, see the detailed chemical profile from the National Institutes of Health (NIH):
NIH PubChem – Azithromycin.
Product Information
- Chemical Name: Azithromycin Dihydrate
- CAS Number: 117772-70-0
- Grade: Veterinary API
- Appearance: White to almost white crystalline powder
- Purity (Assay): 96.0% – 102.0% (anhydrous basis) :contentReference[oaicite:2]{index=2}
- Solubility: Practically insoluble in water; freely soluble in ethanol and methylene chloride
- Specific Optical Rotation: –49 to –45 (anhydrous) :contentReference[oaicite:3]{index=3}
- pH (1% solution): 9.0 – 11.0
- Water Content: 1.8% – 6.5% (Karl Fischer)
- Sulfated Ash: ≤0.2%
Technical Specifications
| Identification | Infrared absorption |
| Appearance of Solution | Clear and colorless |
| pH | 9.0 – 11.0 |
| Specific Optical Rotation | –49 to –45 (anhydrous basis) |
| Water Content | 1.8% – 6.5% |
| Sulfated Ash | ≤ 0.2% |
| Related Substances | Conforms (total impurities ≤ 3.0%) |
| Assay | 96.0% – 102.0% (anhydrous basis) |
Quality Assurance
- Produced under GMP-aligned quality systems.
- Batch-specific COA including assay, impurities, water content, and particle appearance.
- Full documentation support: COA, MSDS, TDS, and Certificate of Origin.
- Each batch undergoes HPLC analysis to ensure purity and impurity control.
- Stable packaging for long-term transport and storage.
Applications & Dosage
Applications:
- Used in veterinary formulations to control bacterial respiratory and enteric infections.
- Effective against Mycoplasma, Pasteurella, and other sensitive organisms in livestock and poultry.
- Suitable for producing oral powders, premixes, and water-soluble preparations.
Typical Dosage (for formulation manufacturers):
- Premix formulations: commonly 5%–20% active inclusion depending on the final product.
- Water-soluble powders: adjusted according to target species and product specifications.
Note: Dosage listed above is for manufacturers and not for direct use on animals. End-users should follow approved veterinary product labels.
Product FAQ
1. What is Azithromycin Dihydrate used for?
It is primarily used in veterinary formulations to target respiratory and enteric infections caused by susceptible bacteria and Mycoplasma species.
2. Is Azithromycin Dihydrate equivalent to Azithromycin anhydrous?
Both share the same active structure, but the dihydrate form contains crystal-bound water, influencing stability and handling in formulations.
3. What types of veterinary products use Azithromycin Dihydrate?
Common applications include premixes, oral powders, and water-soluble preparations for poultry and livestock.
4. How should this API be stored?
Store in a tightly sealed container in a dry environment to prevent moisture uptake and maintain stability.
Q1. How can I request a quotation or sample?
You can click the “Send Inquiry” button on this page or email us directly at [email protected].
Samples are available for most products, and our sales team will reply within 24 hours with detailed pricing and documentation .
Q2. What is the minimum order quantity (MOQ)?
The MOQ is 0.5 kg for most products.
For laboratory evaluation or small trial batches, smaller quantities can be arranged depending on stock availability.
Q3. What certifications do your products comply with?
Our GMP-certified partners operate under ISO, CEP, and FSC standards.
Each batch is supplied with a full set of COA, MSDS, and export documents to ensure quality traceability.
Q4. How long does delivery take?
Usually 3–7 working days for available stock and 2–3 weeks for customized specifications or large orders.
Q5. Which payment methods do you accept?
We accept T/T, L/C, and other agreed terms depending on the order volume and region.
Q6. Can you provide contract manufacturing or custom formulation support?
Yes. We cooperate with multiple GMP facilities to offer custom synthesis, formulation, and registration support for specific markets.
Packaging Information
Standard packing: 25 kg fiber drum or 1 kg foil bag
Double PE inner liner for moisture protection
Custom packaging available on request
Storage & Stability
Store in a cool, dry environment away from direct light. Shelf life 24 months under recommended conditions.
Transportation
Shipped by air, sea, or express according to customer preference. Dangerous goods comply with IATA/IMDG standards if applicable.
Our company and partner facilities hold valid GMP and ISO certificates issued by national authorities, ensuring that every batch meets strict quality and traceability standards required for international veterinary API markets.
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