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CAS No.None

Doxycycline Hyclate

CAS No.

24390-14-5

Appearance

Light yellow to yellow crystalline powder

Purity

≥98%

Molecular Formula

C22H24N2O8·HCl

Molecular Weight

480.90

Solubility

Freely soluble in water; slightly soluble in methanol

Synonyms

Doxycycline hydrochloride hemihydrate; Doxycycline hyclate API; Doxy HCL

Doxycycline Hyclate is a broad-spectrum tetracycline antibiotic widely used in veterinary formulations to treat respiratory, intestinal, and systemic infections in poultry, livestock, and aquaculture.

Overview

Doxycycline Hyclate is a semi-synthetic tetracycline antibiotic widely used in veterinary medicine for the prevention and treatment of bacterial and Mycoplasma infections.
It offers excellent oral absorption, high bioavailability, and strong tissue penetration, making it suitable for poultry, swine, ruminants, and aquaculture applications.

It is especially effective against:
• *Mycoplasma spp.*
• *Pasteurella multocida*
• *E. coli* and other Gram-negative bacteria
• Rickettsiae and Chlamydia

Doxycycline Hyclate is commonly used in soluble powder, premix, and injectable formulations for large-scale flock and herd treatment.

You may also check our Tylosin Tartrate and Doxycycline Hyclate Premix products for related veterinary uses.

Product Information

Active Ingredient: Doxycycline Hyclate (≥98%)
Grade: Veterinary Grade / Pharmaceutical Grade API
Standard: In-house specification aligned with EP/USP
Form: Light yellow crystalline powder
Odor: Characteristic
Packaging: 25 kg fiber drum or as customized
Shelf Life: 36 months in original sealed packaging
Storage: Store below 25°C, protected from light and moisture.

Technical Specifications

Appearance	Light yellow crystalline powder
Identification	Meets IR and HPLC requirements
Assay (on dry basis)	≥98.0%
pH (1% solution)	2.0 – 3.0
Specific Optical Rotation	+90° to +105°
Loss on Drying	≤6.0%
Heavy Metals	≤20 ppm
Related Substances	≤2.0% total impurities
Residue on Ignition	≤0.5%
Solubility	Freely soluble in water
Standard	In-house / EP / USP reference

Reference: .drugs.com

Quality Assurance

Our Doxycycline Hyclate is manufactured under GMP-certified facilities with full regulatory traceability:

• Batch-specific COA, MSDS, and export documents available
• Tested for assay, purity, pH, heavy metals, and related substances
• Compliance with international veterinary API standards (EP/USP aligned)
• Strict control of moisture, temperature, and packaging integrity
• Professional documentation support for worldwide registration

Applications & Dosage

Doxycycline Hyclate is widely used in poultry, livestock, and aquaculture for the treatment of:

• Chronic respiratory disease (CRD)
• Colibacillosis
• Pasteurellosis
• Mycoplasma infections
• Enteritis caused by susceptible bacteria

Recommended Dosage

Poultry:
• 10–20 mg per kg body weight per day for 3–5 days
• Or 100 g per 200–400 L drinking water (depending on infection severity)

Swine:
• 10 mg per kg body weight per day for 3–5 days

Aquaculture:
• 20–50 mg per kg feed for 5–7 days

*Dosage may vary depending on formulation and local veterinary guidelines.*

Product FAQ

1. What is the main advantage of Doxycycline Hyclate?

Doxycycline offers better absorption and fewer interactions compared to older tetracyclines, providing fast and reliable therapeutic levels.

2. Can it be used in combination with other antibiotics?

Avoid combining with penicillins or cephalosporins due to antagonism. It may be used with macrolides or fluoroquinolones following veterinary guidance.

3. Is Doxycycline stable in premix and soluble powder formulations?

Yes. It remains stable when stored in cool, dry, airtight packaging away from light.

4. What is the withdrawal period?

Typically 5–7 days for meat, depending on local regulations. Always follow your country’s veterinary requirements.

5. Do you provide full regulatory support?

Yes — COA, MSDS, TSE/BSE statement, GMP certificate, and registration documents are available for global markets.

Q1. How can I request a quotation or sample?

You can click the “Send Inquiry” button on this page or email us directly at [email protected].

Samples are available for most products, and our sales team will reply within 24 hours with detailed pricing and documentation .

Q2. What is the minimum order quantity (MOQ)?

The MOQ is 0.5 kg for most products.

For laboratory evaluation or small trial batches, smaller quantities can be arranged depending on stock availability.

Q3. What certifications do your products comply with?

Our GMP-certified partners operate under ISO, CEP, and FSC standards.

Each batch is supplied with a full set of COA, MSDS, and export documents to ensure quality traceability.

Q4. How long does delivery take?

Usually 3–7 working days for available stock and 2–3 weeks for customized specifications or large orders.

Q5. Which payment methods do you accept?

We accept T/T, L/C, and other agreed terms depending on the order volume and region.

Q6. Can you provide contract manufacturing or custom formulation support?

Yes. We cooperate with multiple GMP facilities to offer custom synthesis, formulation, and registration support for specific markets.

Packaging Information

Standard packing: 25 kg fiber drum or 1 kg foil bag
Double PE inner liner for moisture protection
Custom packaging available on request

Storage & Stability

Store in a cool, dry environment away from direct light. Shelf life 24 months under recommended conditions.

Transportation

Shipped by air, sea, or express according to customer preference. Dangerous goods comply with IATA/IMDG standards if applicable.

Company Certifications

Our company and partner facilities hold valid GMP and ISO certificates issued by national authorities, ensuring that every batch meets strict quality and traceability standards required for international veterinary API markets.