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Tiamulin Fumarate
CAS No.
Appearance
Purity
Molecular Formula
Molecular Weight
Solubility
Synonyms
Table of Contents
Overview
Tiamulin Fumarate is a semi-synthetic pleuromutilin antimicrobial used for the control of Mycoplasma infections and major bacterial respiratory diseases in swine and poultry. It shows high potency, excellent tissue penetration, and reliable safety when administered through feed or drinking water.
Known for its selective spectrum and strong activity against Mycoplasma and Brachyspira species, Tiamulin Fumarate remains a key active ingredient in modern livestock health programs and is widely adopted by feed manufacturers and veterinary pharmaceutical producers.
Product Information
Active Ingredient: Tiamulin Fumarate
Chemical Class: Pleuromutilin antimicrobial
Grade: Veterinary API (USP compliant)
CAS No.: 55297-96-6
Molecular Weight: 609.82
Formula: C28H47NO4S·C4H4O4
Appearance: White to off-white crystalline powder
Mechanism of Action:
Tiamulin binds to the 50S ribosomal subunit of susceptible bacteria, inhibiting protein synthesis. It exhibits strong activity against Mycoplasma spp., Brachyspira spp., and Gram-positive organisms.
Key Features:
- High activity against Mycoplasma-related respiratory disease
- Excellent bioavailability and tissue distribution
- Reliable efficacy and safety for swine and poultry
- Complies with USP impurity limits and identification tests
Technical Specifications
| Appearance | White to off-white crystalline powder |
| Specific Rotation | +24° to +28° (USP) |
| Identification | IR conforms; HPLC retention time matches standard |
| pH (10 mg/mL) | 3.1 – 4.1 |
| Clarity & Color of Solution | Clear, colorless; absorbance ≤0.150 (400 nm) / ≤0.030 (650 nm) |
| Assay (on dried basis) | 97.0% – 102.0% |
| Content of Fumarate | 83.7 – 87.3 mg |
| Related Substances | Any specified impurity ≤1.0% Any unspecified impurity ≤0.5% Total impurities ≤3.0% |
| Loss on Drying | ≤0.5% |
| Residue on Ignition | ≤0.1% |
| Standard | USP |
Quality Assurance
Our Tiamulin Fumarate is manufactured in GMP-certified facilities with full compliance to USP standards. Each batch is tested for assay, identification, optical rotation, fumarate content, impurities, loss on drying, and solution clarity.
Available Documents:
- Certificate of Analysis (COA)
- Material Safety Data Sheet (MSDS)
- USP-compliant manufacturing record
- Veterinary registration dossier support
All products are packaged in sealed, light-resistant containers to ensure stability and quality throughout transport and storage.
Reference: European Pharmacopoeia veterinary antimicrobial standards.
Applications & Dosage
Applications:
- Control of Mycoplasma infections in swine and poultry
- Treatment of swine dysentery (Brachyspira hyodysenteriae)
- Treatment of ileitis and enzootic pneumonia
- Respiratory disease complex in poultry
Typical Dosage:
(Varies by formulation; consult local veterinary guidelines)
- Swine (premix or water-soluble): 5–20 mg tiamulin/kg body weight/day
- Poultry: 20–50 mg tiamulin/kg body weight/day
Administration Routes:
- Feed premix
- Oral solution in drinking water
Withdrawal Period:
Follows local regulatory requirements (commonly 5–7 days for meat animals).
Product FAQ
Q1: What is the main use of Tiamulin Fumarate?
Tiamulin Fumarate is primarily used for controlling Mycoplasma infections, swine dysentery, ileitis, and respiratory diseases in pigs and poultry.
Q2: How does Tiamulin Fumarate work?
It inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, showing strong activity against Mycoplasma and Brachyspira species.
Q3: What is the classification of Tiamulin?
Tiamulin belongs to the pleuromutilin class of antimicrobials, distinct from macrolides and tetracyclines.
Q4: Is Tiamulin considered a macrolide?
No. Tiamulin is not a macrolide; it is a pleuromutilin derivative with a different chemical structure and mechanism of action.
Q5: How is Tiamulin Fumarate commonly administered?
It is typically administered via feed premixes or drinking-water solutions, depending on the target species and local veterinary guidelines.
Q1. How can I request a quotation or sample?
You can click the “Send Inquiry” button on this page or email us directly at [email protected].
Samples are available for most products, and our sales team will reply within 24 hours with detailed pricing and documentation .
Q2. What is the minimum order quantity (MOQ)?
The MOQ is 0.5 kg for most products.
For laboratory evaluation or small trial batches, smaller quantities can be arranged depending on stock availability.
Q3. What certifications do your products comply with?
Our GMP-certified partners operate under ISO, CEP, and FSC standards.
Each batch is supplied with a full set of COA, MSDS, and export documents to ensure quality traceability.
Q4. How long does delivery take?
Usually 3–7 working days for available stock and 2–3 weeks for customized specifications or large orders.
Q5. Which payment methods do you accept?
We accept T/T, L/C, and other agreed terms depending on the order volume and region.
Q6. Can you provide contract manufacturing or custom formulation support?
Yes. We cooperate with multiple GMP facilities to offer custom synthesis, formulation, and registration support for specific markets.
Packaging Information
Standard packing: 25 kg fiber drum or 1 kg foil bag
Double PE inner liner for moisture protection
Custom packaging available on request
Storage & Stability
Store in a cool, dry environment away from direct light. Shelf life 24 months under recommended conditions.
Transportation
Shipped by air, sea, or express according to customer preference. Dangerous goods comply with IATA/IMDG standards if applicable.
Our company and partner facilities hold valid GMP and ISO certificates issued by national authorities, ensuring that every batch meets strict quality and traceability standards required for international veterinary API markets.
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