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Tilmicosin Phosphate (CAS 137330-13-3) veterinary antibiotic API powder

Tilmicosin Phosphate

CAS No.
137330-13-3
Appearance
White to off-white powder

Purity

≥ 80%

Molecular Formula

C46H80N2O13 · H3PO4

Molecular Weight

949.2

Solubility

Soluble in methanol; slightly soluble in water

Synonyms

Tilmicosin phosphate
Tilmicosin Phosphate is a semi-synthetic macrolide antibiotic used in veterinary medicine for prevention and control of respiratory infections in poultry and livestock.

Table of Contents

Overview

Tilmicosin Phosphate is a macrolide veterinary antibiotic derived from Tylosin. It inhibits protein synthesis by binding to the 50S ribosomal subunit and is widely used for the prevention and treatment of respiratory diseases in poultry, swine, cattle, and small ruminants.

Compared with Tilmicosin base, the phosphate form offers improved stability, better solubility in formulation processing, and enhanced compatibility for premix, oral solution, and powder applications.

You may also check our Doxycycline Hyclate and Tylosin Tartrate for related veterinary API solutions.

Product Information

• **Active Ingredient:** Tilmicosin Phosphate
• **Assay (as Tilmicosin):** 85.0% typical (on anhydrous basis)
• **Description:** White to off-white crystalline powder
• **Grade:** Veterinary grade
• **Mode of Action:** Inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit
• **Target Pathogens:** Mycoplasma spp., Pasteurella multocida, Mannheimia haemolytica, Actinobacillus spp.
• **Applications:** Premix, soluble powder, oral liquid formulations
• **Shelf Life:** 24 months (manufacturer COA)
• **Storage:** Preserve in tightly closed, light-resistant containers; avoid excessive heat

Technical Specifications

Item Specification Result
Appearance White to off-white powder Complies
Identification • IR spectrum conforms to reference
• HPLC retention time conforms to standard
Complies
Specific Rotation +24° to +28° +26°
pH 3.1 – 4.1 3.6
Assay (as Tilmicosin) ≥ 85% 85.6%
Water Content ≤ 5.0% 2.23%
Related Substances • Any individual impurity ≤1.0%
• Unspecified impurity ≤0.5%
• Total impurities ≤3.0%
Complies
Loss on Drying ≤ 2.0% 0.35%
Residue on Ignition ≤ 0.1% 0.05%

Reference: European Pharmacopoeia veterinary macrolide standards.

Quality Assurance

Our Tilmicosin Phosphate is produced under GMP-certified facilities with strict quality control procedures, including:

• Full testing of assay, impurities, water, and physical characteristics
• Compliance with in-house specifications aligned with USP veterinary standards
• Batch-specific COA, MSDS, and export documents available
• Controlled storage and packaging to maintain product stability
• Pharmaceutical-grade production lines for veterinary macrolide antibiotics

Applications & Dosage

**Applications**
Tilmicosin Phosphate is used in veterinary formulations for the prevention and treatment of respiratory infections in swine, poultry, cattle, and sheep.

**Typical Dosage (for reference)**
• **Poultry:** 75–100 mg/kg feed for 3–5 days
• **Swine:** 200–400 mg/L drinking water for 5–7 days
• **Ruminants:** According to local veterinary regulations

*Note: Actual dosage depends on local regulations and formulation requirements.*

Product FAQ

1. What is Tilmicosin Phosphate used for?
Tilmicosin Phosphate is used in veterinary formulations for preventing and treating respiratory infections caused by Mycoplasma spp., Pasteurella multocida, and Mannheimia haemolytica in poultry, swine, and cattle.

2. How does Tilmicosin Phosphate work?
It inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, suppressing growth of susceptible Gram-positive bacteria and Mycoplasma species.

3. What is the difference between Tilmicosin Phosphate and Tilmicosin Base?
The phosphate form offers better stability, improved solubility during formulation, and higher compatibility for premix, soluble powder, and oral liquid applications.

4. Is Tilmicosin Phosphate water-soluble?
It shows improved water dispersibility compared with Tilmicosin base, making it suitable for soluble powder and oral liquid formulations.

5. What types of veterinary formulations commonly use Tilmicosin Phosphate?
It is widely used in premixes, soluble powders, oral solutions, and combination macrolide-based respiratory treatments.

Q1. How can I request a quotation or sample?

You can click the “Send Inquiry” button on this page or email us directly at [email protected].

Samples are available for most products, and our sales team will reply within 24 hours with detailed pricing and documentation .

Q2. What is the minimum order quantity (MOQ)?

The MOQ is 0.5 kg for most products.

For laboratory evaluation or small trial batches, smaller quantities can be arranged depending on stock availability.

Q3. What certifications do your products comply with?

Our GMP-certified partners operate under ISO, CEP, and FSC standards.

Each batch is supplied with a full set of COA, MSDS, and export documents to ensure quality traceability.

Q4. How long does delivery take?

Usually 3–7 working days for available stock and 2–3 weeks for customized specifications or large orders.

Q5. Which payment methods do you accept?

We accept T/T, L/C, and other agreed terms depending on the order volume and region.

Q6. Can you provide contract manufacturing or custom formulation support?

Yes. We cooperate with multiple GMP facilities to offer custom synthesis, formulation, and registration support for specific markets.

Packaging Information

  • Standard packing: 25 kg fiber drum or 1 kg foil bag

  • Double PE inner liner for moisture protection

  • Custom packaging available on request

Storage & Stability

Store in a cool, dry environment away from direct light. Shelf life 24 months under recommended conditions.

Transportation

Shipped by air, sea, or express according to customer preference. Dangerous goods comply with IATA/IMDG standards if applicable.

Company Certifications
Company quality and compliance certificates

Our company and partner facilities hold valid GMP and ISO certificates issued by national authorities, ensuring that every batch meets strict quality and traceability standards required for international veterinary API markets.

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