Repel roundworms
The ethanol extract of neem bark has a paralyzing effect on Ascaris suum, especially the Ascaris suum in vitro, and its effective ingredient Chuanmusu is stronger than that of Neem bark extract. The effect of different concentrations of Chuanzhusu on Ascaris suum was mildly, moderately to completely inhibited with increasing concentration, and then the activity could be gradually restored. For the whole pig Ascaris, Chuanmadin is paralyzed at high concentration, and low concentration has obvious excitatory effect on Ascaris suum, causing violent contraction, which can disturb the energy metabolism of the worm body and prevent the worm body from attaching to the intestinal wall and being excreted from the body. The main site of action of Chuanzhong is the nerve ring of the head of Ascaris lumbricoides. After oral administration of Chuanmusu to monkeys, the drug is absorbed and distributed quickly in the body, distributed widely, and eliminated slowly. The concentration of the drug in the tissues is highest in the gallbladder, liver and duodenum, followed by the spleen and kidneys, and is present in various parts of the brain. Evenly distributed, but low concentration. Repeated administration for many times is accumulative. Junzi decoction and ethanol extract can inhibit Ascaris suum. The water-soluble part of Gentleman’s Seed extract has a paralyzing effect on Ascaris suum. The deworming effect of gentleman has nothing to do with the removal of sugar, ash and potassium oxalate by fermentation of the extract. Its active ingredient is potassium gentlemanate, which has a high insect repellent effect. The high concentration of gentleman excites roundworms first and then paralyzes. This excitement is also one of the reasons for the deworming effect.
Repellent
Arecoline is the effective ingredient of betel nut to repel tapeworms. It has a strong paralyzing effect on all parts of the pork tapeworm, while its effect on beef tapeworm only paralyzes the head and immature segments, and the pregnant egg segment (middle and posterior segment) Also affected and softened, but not completely paralyzed, the effect is poor. Betel nut has a strong paralyzing effect on tapeworms with hook tapeworms, tapeworms without hook tapeworms and short tapeworms. Pumpkin seed decoction and its extract make the middle and posterior segments of beef tapeworm thinner and wider, the middle part of the segment is sunken and paralyzed, and the head and immature segments move freely. Using L-perchlorate cucurbitine and synthetic dl-hydrobromide cucurbitine to treat dogs with tapeworm disease, both can deworm. It has a paralyzing effect on the immature and mature segments of the canine vesicular tapeworm, the bean-shaped tapeworm, and therefore the entire tapeworm is often excreted. Cucurbitine is effective in treating tapeworms in cats, and it is also effective against Hymenoderma brevisiae in mice. Thunder pills can also repel tapeworms. “Materia Medica” records that Lei Wan “kills three insects”. The main active ingredient is Lewandan, which is a protease with a content of about 3%. It can decompose protein in a weakly alkaline solvent (pH 8). In vitro experiments have proved that the water extract of Lei Wan can kill the tapeworm segments. Its effect is due to the decomposition of the protein of the worm body by the protease, destroying the worm body, and it may not be found in the enlarged stool. Its curative effect can be due to long-term fecal examination, repeated negative And be affirmed.
Repelling pinworms
The Junzi powder has no effect on repelling adult pinworms in mice, but it has a more significant repellent effect on mature females and females with eggs full of uterus. In vitro experiments of betel nut powder and decoction have a paralytic effect on mouse pinworms and can repel its adults, but the effect is not as good as human pinworms. Betel nut powder also has a slight effect on the larvae of pinworms.
Hookworm
In vitro experiment of neem root bark decoction on hookworm canine can kill all of them at high concentration. The decoction of betel nut slices can also kill hookworms. Some females rupture their tails, expose their uterus, and curl their bodies.
Whipworm
Both betel nut decoction and mixture (betel nut, ebony, licorice) can repel whipworm and ginger worm.
Anti-schistosomiasis
Pumpkin seeds were given on the day the mice were infected with schistosome. 28 days was a course of treatment. The preventive effect was the best, the number of worms was significantly reduced, and it had no effect on the adult schistosomes. Pumpkin seed acetone extract and cucurbitine can inhibit the growth and development of young worms, and have preventive effects, but cannot kill the adult schistosomes in mice. They can only atrophy the sexes, degenerate the reproductive organs and the number of eggs in the uterus. reduce. When cucurbitine and tartar are combined in the treatment of schistosomiasis in mice, the two drugs are administered at the same time or the spittar is first followed by the cucurbitaline for the best effect, and the cucurbitine is administered first and then the tartarite is generally administered. Poor efficiency. After oral administration of cucurbitine, the liver cells showed mild atrophy or a small amount of fat infiltration in the liver, which returned to normal after stopping the drug.
